Tim B. Dyrby BSc.EE, MSc, Ph.D

DIG Group Leader

Office (+45) 38 62 65 42

Email: timd |at| drcmr.dk 

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Engineer with many years experience in the medical imaging field, both clinic and pre-clinic.

Research Keywords

Microstructure imaging 
Tractography
Brain plasticity and maturation
Neuro-anatomy
MR acqusition and sequence design

Education

Feb. 2005 – Oct. 2008 entitled: Modelling Brain Tissue Using Magnetic Resonance Imaging

 PhD with affiliation at:

1) Memory of Disorders Unit, Cph. Univ. Hosp,
2) DRCMR, Cph. Univ. Hosp. Hvidovre,
3) Section for Cognitive Systems, DTU Informatics, Tech. Univ. of Denmark

August 1999-Juni 2002  MSc at Informatics and Mathematical Modeling, Tech. Uni. of DK

January 1993-June 1997 Diploma Engineer, B.Sc.EE at Dep. of Electronics, Engineering College of Copenhagen, Denmark


Employment

Jan. 2011 -  Senior researcher

Jan. 2009 -             Group leader, Diffusion Imaging Group (DIG), DRCMR

Oct. 2008 - Dec. 2010     Postdoc, DRCMR

Sep. 2003 – Feb. 2005     Research Assistant, DRCMR. Working on the EU project: "The LADIS study"

Sep. 2002 – Sep. 2003   Research Assistant, Neurobiologic Research Unit, Copenhagen University Hospital Rigshospitalet. Working on the EU project: "PVEOut"

Aug. 1997 - May 2000     INTRA Development A/S (Electronic development company)


Research activity and experience

  • Supervisoring five Phd-students and postdoc's.
  • PI of the Danish part of the CONNECT project (Consortium for the Non-Invasive Exploration of Connectivity and Tracts) supported by European Commission (FP7), 2010-2011 (www.brain-connect.eu).  
  • Faculty member at the conference Int. Soc. for Magn. Res. in Med,  course: Validation of crossing fibre (2009, Hawaii, USA), and Tractography–Beyond the usual talks (2008, Toronto, Canada)
  • Organizer: Diffusion MRI workshop (2009, 2006). DRCMR, Cph. Univ. Hosp Hvidovre
  • Organizer/teaching: PhD course Advances in MRI of human brain structure and function, Cph Uni. 2009 
  • Program committee MICCAI on Computational Diffusion MRI (CDMRI), 2010,2011, 2012 
  • MICCAI 2010 Workshop on Computational Diffusion MRI (CDMRI'10), Beijing China, Lecture: ”Validation approaches for diffusion MRI based techniques” 
  • Selected invited talks: Oxford (2007), Manchester (2007), Israel (2008, 2011).
  • Reviewer: Neuroimage, Human Brain Mapping, Hippocampus, Brain Structure and Function, NMR in Biomedicine, MRM
  • Large scale data (multi-center) and image processing and analysis
  • Pre-clinical MRI experience (in vivo and ex vivo)
  • Clinical MRI experience  

Popular Science

2009 På opdagelse i hjernen med lovende teknik (in Danish), Videnskab.dk

2009 På opdagelse i hjernen (in Danish), Front page on the DTUAvisen (April) the newspaper of The Technical University of Denmark

2011 På rundrejse i den levende hjerne med MR. Forskningendøgn, Hvidovre Hospital  

 

Recent Publications 

Lundell H, Barthelemy D, Biering-Sørensen F, Cohen-Adad J, Nielsen JB, Dyrby TB., Fast diffusion tensor imaging and tractography of the whole cervical spinal cord using point spread function corrected echo planar imaging., Magn Reson Med. 2012 Mar 6. doi: 10.1002/mrm.24235. [Epub ahead of print]

Zhang H, Dyrby TB, Alexander DC.,Axon diameter mapping in crossing fibers with diffusion MRI., Med Image Comput Comput Assist Interv. 2011;14(Pt 2):82-9.

Lundell H, Nilsen JB, Ptito M, Dyrby TB, Distribution of collateral fibers in the monkey cervical spinal cord detected with diffusion weighted magnetic resonance imaging, Neuroimage, 2011, 1;56(3):923-9.

Dyrby TB, Baaré WF, Alexander DC, Jelsing J, Garde E, Søgaard LV, An ex vivo imaging pipeline for producing high-quality and high-resolution diffusion weighted imaging datasets, Hum Brain Mapp. 2011;32(4):544-63

Lundell H, Barthelemy D, Skimminge A, Dyrby TB, Biering-Sørensen F, Nielsen JB. Independent spinal cord atrophy measures correlate to motor and sensory deficits in individuals with spinal cord injury. Spinal Cord. 2010

Alexander DC, Hubbard PL, Hall MG, Moore EA, Ptito M, Parker GJ, Dyrby TB. Orientationally invariant indices of axon diameter and density from diffusion MRI Neuroimage. 2010 :1374-89

Dyrby TB, Rostrup E, Baaré WF, van Straaten EC, Barkhof F, Vrenken H, Ropele S, Schmidt R, Erkinjuntti T, Wahlund LO, Pantoni L, Inzitari D, Paulson OB, Hansen LK, Waldemar G; LADIS study group. Segmentation of age-related white matter changes in a clinical multi-center study. Neuroimage, Vol 41, pp. 335-45, 2008

Dyrby TB, Sogaard LV, Parker GJ, Alexander DC, Lind NM, Baare WF, Hay-Schmidt A, Eriksen N, Pakkenberg B, Paulson OB, Jelsing J., Validation of in vitro probabilistic tractography. Neuroimage, Vol 37, pp. 1267-1277. 2007

Haugbol S, Pinborg LH, Arfan HM, Frokjaer VM, Madsen J, Dyrby TB, Svarer C, Knudsen GM. Reproducibility of 5-HT2A receptor measurements and sample size estimations with [18F]altanserin PET using a bolus/infusion approach. Eur J Nucl Med Mol Imaging, Vol 34, pp. 910-5. 2007

Jelsing J, Hay-Schmidt A, Dyrby T, Hemmingsen R, Uylings HB, Pakkenberg B. The prefrontal cortex in the Gottingen minipig brain defined by neural projection criteria and cytoarchitecture. Brain Res Bull, Vol 70, pp. 322-36, 2006


Conference contributions

Sønderby C., Lundell H., Dyrby TB., Assessing exchange between multiple compartments using multi-directional double wave diffusion sequences, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), pp.352, 2012, Melbourne, Australia, Oral

Lundell, H., Sønderby C., Vejby Søgaard, L, Dyrby TB., DTI using modulated gradients at short effective diffusion times, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), pp.355, 2012, Melbourne, Australia, Oral

Reislev N., Ptito M., Kupers R., Siebner H., Dyrby TB., Alterations of the inferior longitudinal fasciculus in congenital and late blindness, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), pp.3706, 2012, Melbourne, Australia, Poster

Zhang H., Dyrby TB., Alexander D., Axon diameter mapping in crossing fibers with diffusion MRI, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), pp.1828, 2012, Melbourne, Australia, Poster

Alexander D., Dyrby TB., Compensation for bias from unwanted gradient contributions in STEAM diffusion MRI, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), pp.1884, 2012, Melbourne, Australia, Poster

Hubbard P., Zhou F., Eichhorn S., Dyrby TB., G. Parker., A biomimetic phantom of white matter for application in diffusion MRI, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), pp.1939, 2012, Melbourne, Australia, Poster

Lyksborg M., Larsen R., Sørensen P., Blinkenberg M., Dogonowski A., Garde E., Parker G., Siebner S., Dyrby TB., Anatomical Connectivity Mapping – Measuring connectivity changes in Multiple Sclerosis, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), pp.501, 2012, Melbourne, Australia, Oral

Lyksborg M., Lundell H., Reislev N., Siebner H., Larsen R., Dyrby TB., Correcting geometric distortions of Echo Planar Imaging using demons and reversed phase encoding, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), pp.2578, 2012, Melbourne, Australia, Poster

Comparison of Diffusion Tractography and Manganese Tracing, T.R. Knösche, A. Anwander, M. Liptrot, T.B. Dyrby, (Proceedings paper) OHBM, 2011, abstract number 4267, Quebec, Canada, poster

Interpolation of DWI prior to DTI reconstruction, and its validation, T.B. Dyrby, H.M. Lundell, M.G. Liptrot, M.W. Buke, M. Ptito, H.R. Siebner. (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), 2011, Montreal, Canada, poster

Microstructure Tracking (MicroTrack): An Algorithm for Estimating a Multiscale Hierarchical White Matter Model from Diffusion-Weighted MRI.  A.J. Sherbondy, T.B. Dyrby, M.C. Rowe, M. Ptito, B.A. Wande, D.C. Alexander, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM). 2011, (pp. 679). Montreal, Canada, Oral

A comparative study of axon diameter imaging techniques using diffusion MRI, H. Zhang, D. Barazany, Y. Assaf, H.M. Lundell, D.C. Alexander, T.B. Dyrby, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), 2011, (pp. 576 - 576). Montreal, Canada, Oral

Dependence of axon diameter index on maximum gradient strength, T.b. Dyrby, P.L. Hubbard, M. Ptito, M.G. Hall, D.C. Alexander, (Proceedings paper)International Society for Magnetic Resonance in Medicine (ISMRM), 2010, (pp. 83). Stockholm, Sweden, Oral

Optimized diffusion MRI protocols for estimating axon diameter with known fibre  orientation, T. Schneider, H. Lundell, T. B. Dyrby, D. C. Alexander, and C. A. Wheeler-Kingshott, (Proceedings paper) International Society for Magnetic Resonance, 2010, Stockholm, Sweden, poster

How Many Streamlines Should I Use?, M.G. Liptrot, T.B. Dyrby, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM). 2010, Pp 4015. Stockholm, Sweden, Electronic poster

Comparision study of the human brain using histology, stereology and MRI, A.S. Karlsen, T.B. Dyrby, B. Pakkenberg, 2010, Society for Neuroscience (sfn), San Diego, USA, Poster

Anatomical Organization of the Blind's Brain: Combined VBM and DTI Analysis. Wang Z;Baare WFC;Dyrby TB;Paulson OB;Kupers R;Ptito M. Poster, Annu Meet Organ Hum Brain Map 2009, Neuroimage 47(Suppl 1), 613 F-AM.

Orientationally invariant axon-size and density weighted MRI, D. C. Alexander, P. L. Hubbard, M. G. Hall, E. A. Moore, M. Ptito, G. J. Parker, T. B. Dyrby,  (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), 2009, Honolulu, Hawaii, Oral

Addressing the problem of path-length dependency in probabilistic tractography – The ICE-T framework, M. G. Liptrot, K. Sidaros, T. B. Dyrby , (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), 2009, Honolulu, Hawaii, Poster

Longitudinal changes in diffusivity after long-term storage of postmortem tissue, T. B. Dyrby, W. F. Baaré, D. C. Alexander, J. Jelsing, E. Garde, L. V. Søgaard, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), 2009, Honolulu, Hawaii, Poster

Estimation of Multiple Fibre Orientations using Convex Optimization, J. E. Cisternas, T. B. Dyrby, T. Asahi, M. Galvez, G. Rojas , (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), 2009, Honolulu, Hawaii, Poster

Regularized Q-ball Reconstruction: Robust estimation, model selection, and spatial denoising, J. E. Cisternas, P. Daza, T. Asahi, T. B. Dyrby, K. Fritzsche, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), 2009, Honolulu, Hawaii, Poster

Crossing fibers in lateral white matter of the cervical spinal cord detected with diffusion MRI in monkey postmortem, H. Lundell, T. Dyrby, M. Ptito, J. B. Nielsen (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), 2009, Honolulu, Hawaii, Poster

Cervical  corticospinal terminations visualized with diffusion MRI in the monkey spinal cord in vitro, H. Lundell, J. B. Nielsen M. Ptito, T. Dyrby, Proc Human Brain mapping, 2009, San Fransisco, USA, Poster

Diffusion Tensor Imaging and Tractography, Dyrby TB, Brain and Mind Forum, 2007, Helsinge, Denmark, Oral

Validation of multi-fibre probabilistic tractography of corticothalamic projections in the Göttingen minipig brain, Dyrby TB, Vejby Søgaard L, Parker GJ, Alexander DC, Lind NM, Paulson OB and Jelsing J, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), 2005, 1278. (Seattle, USA), Poster

Segmentation of Age-Related White-Matter Changes in a large-scale, multi-centre study, Dyrby T., Rostrup E., E. C. W. van Straaten, Barkhof F., Ropele S, Hansen LK, Waldemar G on behalf of the LADIS study group,  (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), 2005, 1278. (Seattle, USA), Poster

Validation of multi-fibre probabilistic tractography of corticothalamic projections in the Göttingen minipig brain. Dyrby TB, Vejby Søgaard L, Parker GJ, Alexander DC, Lind NM, Paulson OB and Jelsing J, 2006, Forskningsdagen Hvidovre Hospital. Denamrk, Poster

Automatic Segmentation of Age-Related White-Matter Changes in a multi-centre study, C. Ryberg, T. B. Dyrby, E. Rostrup, E. C. W. van Straaten, F. Barkhof, S. Ropele, L. K. Hansen, D. Inzitari, L. Pantoni, G. Waldemar on behalf of the LADIS study group, The 10th International Conference on Alzheimer's Disease and Related Disorders, ICAD, Madrid, Spain, July, 2006, Poster-award

Automatic Segmentation of Age-Related White-Matter Changes in a multi-centre study. C. Ryberg, T. B. Dyrby, E. Rostrup, E. C. W. van Straaten, F. Barkhof, S. Ropele, L. K. Hansen, D. Inzitari, L. Pantoni, G. Waldemar on behalf of the LADIS study group, The Alzheimer's Imaging Consortium in Madrid, Spain, July 15, 2006., Poster

Standardizing MR image Intensity In Multi-Center Studies, Dyrby T. Liptrot MG,
(Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), 2005. (Miami, USA), Oral presentation

Semi-Quantitative Assessment of Inflammation in dMRI using Data Mining Techniques, Liptrot M.G,, Dyrby T, Simonsen H, Søgaard LV, Brandt C, Rowland IJ. (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), 2005, 1278. (Miami, USA), Poster

Validation of Diffusion Tensor Imaging for in vivo tracing of cortico-thalamic projections in the Göttingen minipig brain, Dyrby TB, Lind NM, Vejby Søgaard L, Alexander DC, Parker GJM, Paulson OB  and Jelsing, J Proc Intl Soc Neuroscience 2005, 816.8 (Washington DC, USA), Oral presentation

The prefrontal cortex of the Göttingen minipig brain defined by neural projection criteria and cytoarchitecture, Jelsing J, Hay-Schmidt A, Uylings H.B.M, Dyrby T, Pakenberg B. Proc Intl Soc Neuroscience 2005 (Washington DC., USA), Poster 

Validering af diffusionsvægtet MRI for in vivo tracing af cortico-thalamus projektioner i hjernen af Göttingen minigris, Dyrby TB, Lind NM, Vejby Søgaard L, Alexander DC, Parker GJM, Paulson OB  and Jelsing J, Research Day at Hvidovre Hospital 2005, 65 (Hvidovre, DK), Poster

Alzheimer - den spæde begyndelse. Ramsoy T.Z., Liptrot M.G. Christensen M.S., Lund T.E., Dyrby T, Jernigan T.L., Baare W.F.C., Paulson O.B., Research Day at Hvidovre Hospital 2005, 59 (Hvidovre, DK), Poster

Semi-Quantitative Assessment of Inflammation in dMRI using Data Mining Techniques. Liptrot M.G., Dyrby T, Simonsen H, Søgaard L.V., Brandt C., Rowland I.J., (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), 2005, 1278. (Miami, USA), Poster

Semi-Quantitative Assessment of Inflammation in dMRI using Data Mining, Liptrot M.G., Dyrby T., Simonsen H., Søgaard L.V., Brandt C., Rowland I.J., Techniques. Proc Image Analysis and in Vivo Pharmachology 2005. (Roskilde, DK). Oral

Validation of Diffusion Tensor Imaging (DTI) for non-invasive fibre tracing in the Göttingen minipig), Jelsing J. Dyrby T., 2005, Research Day, Bispebjerg Hospital, Copenhagen DK, Poster

The prefrontal cortex of the Göttingen minipig brain defined by neural projection criteria and cytoarchitecture, Jelsing J, Hay-Schmidt A, Dyrby T, Hemmingsen R, Uylings HB, Pakkenberg B, 2005, Fourth Annual OAK Meeting, Danish Brain Research Lab. Meeting, Aarhus, DK, Oral

The prefrontal cortex of the Göttingen minipig brain defined by neural projection criteria and cytoarchitecture, Jelsing J, Hay-Schmidt A, Dyrby T, Hemmingsen R, Uylings HB, Pakkenberg B., 2005, Neurodag, The Panum Institute, Copenhagen, DK, Poster

PVE-lab:Software for correction of functional images for partial volume errors, Rask T, Dyrby T, Comerci M, Quarantelli M, Alfano B, Berkouk K, Baron J, Colchester A, Hojjat A, Knudsen G.M., Paulson O.B., Svarer C., 2004, Annu Meet Organ Hum Brain Map (WE286). 

RF inhomogenity correction: Validity of the smooth-bias approximation, Hanson LG, Dyrby T.B. 2002, (Proceedings paper) International Society for Magnetic Resonance in Medicine (ISMRM), Hawaii, USA, Poster